July 31, 2019 Kerri-Ann Millar Vice President, Finance Cue Biopharma, Inc. 21 Erie St. Cambridge, MA 02139 Re: Cue Biopharma, Inc. Form 10-K for the Fiscal Year Ended December 31, 2018 Filed March 14, 2019 File No. 001-38327 Dear Ms. Millar: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Healthcare & Insurance